Numerous laboratory and clinical studies suggest that this combination can be of benefit for the cardiovascular system, the immune system, and the nervous system.†
LarchVita™ PLUS offers the benefits of a unique combination of flavonoid DIHYDROQUERCETIN (DHQ) also known as TAXIFOLIN and VITAMIN C. Dihydroquercetin may be of great benefit by enhancing the antioxidant potential of the body's antioxidant network.
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LarchVita™ Dihydroquercetin molecular structure The ORAChydro value of LarchVita™ Dihydroquercetin is over 28,000µM TE/g. |
(Method: ALC114A, AUV203A, AOAC, USP, Journal of Agricultural and Food Chemistry, 2001; 49(10); 4619-4626) * The ORAChydro reflects water-soluble antioxidant capacity. Trolox, a water-soluble Vitamin E analog, is used as the calibration standard and the ORAC result is expressed as micro mole Trolox equivalent (TE) per gram. |
Dihydroquercetin supports cellular structure and cell metabolism. This flavonoid was shown to scavenge free radicals in different lipid peroxidation inhibition assays. It inhibited superoxide radical production and microsomal lipid peroxidation, thus offering antioxidant protection to the mitochondria, cellular membrane, and subcellular systems.
Due to the native molecule structure - functionality relationship with high potency to donate hydrogen atom, dihydroquercetin can penetrate the human erythrocytes easily and protect from oxidative damage (CAP-e assay by NIS Labs*), which in turn confirms LarchVita™ Dihydroquercetin bioavailability in human tissues.
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CAP-e Units per 1 gram: 9.9 -10.5 |
| *CAP-e assay as a cell-based antioxidant protection assay using erythrocytes to address the question of whether antioxidants in complex natural products enter the cytosol and contribute to the reduction of oxidative damage within the cell. | |
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Its antioxidant activity was shown to match antioxidant activity of vitamin E in the peroxidation process of liposome membranes from egg phospholipids induced by ferrous sulfate; to be greater than that of vitamin C in scavenging oxygen anion-radicals; and to greatly exceed that of trolox in vitro lipid peroxidation inhibition assay.
Dihydroquercetin may support healthy cholesterol levels by inhibiting apoB secretion and microsomal triglyceride synthesis.
Dihydroquercetin may inhibit the activity of HMG-CoA reductase and to suppress cellular cholesterol esterification and triacylglycerol and phospholipid syntheses.
Ascorbic acid has specific and well-defined functions in our body. It acts as a co-factor of eight enzymes involved in collagen hydroxylation, biosynthesis of carnitine and norepinephrine, tyrosine metabolism, and other enzymatic reactions. It also acts as a powerful water-soluble antioxidant that reduces harmful oxidants, quenches oxidants generated during phagocytosis, and promotes iron absorption.
Along with other enzymatic and non-enzymatic components of the body’s antioxidant defense system, vitamin C offers protection to the organs, tissues, and cells against reactive oxygen species, thus, ensuring overall well-being of the organism.
Vitamin C is a water-soluble antioxidant capable of neutralizing reactive oxygen species that may have a detrimental effect on our health. Vitamin C was shown to reduce oxygen related radicals, such as superoxide, hydroxyl radical, peroxyl radical; sulphur radicals; and nitrogen-oxygen radicals.
Vitamin C de-activates such compounds as nitrosamines and hypoclrorous acid and reduces transition metal-mediated reactions.
Substantial scientific evidence suggests that the novel combination of the nutrients Dihydroquercetin and Vitamin C confers powerful, synergistic protection against free radicals.
Dihydroquercetin is capable of reducing the ascorbyl radical, thus fulfilling the “ascorbate-protecting function”, while ascorbic acid assists in restoring the bioflavonoid by regenerating its antiperoxidative properties.
Preliminary clinical evidence showed an integral effect of DHQ and Vitamin C on hemorheological parameters including its support in healthy blood viscosity and peripheral blood flow resistance, and healthy blood pressure.
| LarchVita PLUS (Cardio Health) ORAC assay per capsule 3,890 µM TE/g. |
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The CAP-e assay is used to test whether natural products contain antioxidants capable of entering into and protecting live cells from oxidative damage. Thus, when any protective effect is seen in the CAP-e assay, it shows a biologically meaningful antioxidant protection by the product. |
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LarchVita PLUS (Cardio Health) CAP-e units per capsule 261 GA E/g. |
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